MTC - 71 - Purine. 82 terms. A salvage pathway is a pathway in which a biological product is produced from intermediates in the degradative pathway of its own or a similar substance. Mechanism of degradation: 1. These free purines are reconverted to their corresponding nucleotides through salvage pathways. PNP is an enzyme in the purine salvage pathway that metabolizes inosine and guanosine to hypoxanthine. Expert Answer . Moreover, many analogues of purines and pyrimidines are used as chemotherapeutic agents that are introduced into the cell via the salvage pathways. Abstract: For many years, the purine salvage pathway of parasitic protozoa has been regarded as an attractive chemotherapeutic target. Purine nucleoside phosphorylase (PNP) is an enzyme in the nucleotide salvage pathway that occurs in many tissues, but appears to be highest in the liver in hepatocytes, Kupffer cells, and sinusoidal endothelial cells. The de novo synthesis of purine nucleotides requires a great deal of energy in the form of ATP. The end product of purine metabolism in humans is uric acid. {ref4}{ref5}{ref6}{ref7} In the preceding step of the pathway, ADA … In general, the salvage pathway occurs in extrahepatic tissues. Purine salvage begins with the free nitrogenous bases, hypoxanthine and guanine.Guanine combines with PRPP to form GMP, whereas Hypoxanthine combines with PRPP to form IMP.IMP can then be interconverted with AMP.Therefore, salvage of AMP occurs through hypoxanthine. Purine Salvage is a biochemical pathway that recycles partially degraded purine bases to reform purine nucleotides. 66 terms. Explain. The net formation of purine nucleotides is performed by the de novo pathway, but rapid turnover of nucleic acids, especially RNA, is required for nucleotide production by the salvage pathways. Describe how bases are recycled using salvage pathway. OTHER SETS BY THIS CREATOR. Turnover of nucleic acids (particularly RNA) in most cells releases adenine, guanine, and hypoxanthine. The resulting mutants are viable under normal conditions but are hypersensitive to inhibition of purine nucleotide synthesis in their host cell. The nucleotide monophosphates (AMP, IMP and CMP) are converted to their … 37 terms. Where does the salvage pathway occur? ... MBC-52 Purine Metabolism. This can occur either at the level of the recruitment and/or signaling of specific nucleotide or nucleoside receptors or through genetic alterations in key steps of the purine salvage pathway. Biochemistry - Nucleotide Metabolism. Purines can be generated in the cells during the degradation of nucleic acids through salvage pathways. Extra hepatic tissues! PNP activity has been reported to a much lesser extent in heart and muscle. Keywords:Purine salvage pathway, parasitic protozoa, Trypanosoma, Leishmania, Plasmodium, inhibitors, iminoribitols, nucleoside hydrolase. 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